Lai 2007.

Study characteristics
Patient sampling	Study design not clear No inclusion or exclusion criteria reported
Patient characteristics and setting	189 patients Age ranged from 12 to 76 years No information about gender Taiwan Inpatients from intensive care units and haematology/oncology departments Representative spectrum? Unclear: selection criteria and patient population not clearly described
Index tests	Platelia. No further information, except about definition of positive test result and cut‐off values. Positive sample = subsequent samples of ≥ 1.5 ODI
Target condition and reference standard(s)	Invasive aspergillosis, as defined by EORTC criteria (Ascioglu 2002) Incorporation avoided? Yes: galactomannan excluded from criteria Acceptable reference standard? Yes: EORTC criteria (Ascioglu 2002)
Flow and timing	Time interval not reported Partial verification avoided? Yes: all patients were classified according to the reference criteria Withdrawals explained? No Uninterpretable results reported? Yes
Comparative
No patients per category	5 proven, 9 probable, 26 possible, 149 no IA
Notes	Nothing reported about financial support
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Unclear
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Unclear
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Unclear	Unclear
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Unclear
		Unclear