Shi_Y 2009.

Study characteristics
Patient sampling	Seems to be a single‐arm study; consecutive enrolment of patients
Patient characteristics and setting	China; only adults; 94 participants Inpatients admitted to ICU and suffering from suspected IPA Representative spectrum? Yes: seems to be eligible (consecutive enrolment; all suspected of IPA)
Index tests	Platelia; cut‐off is 0.5 ODI (single sample is sufficient); test was done routinely, twice a week
Target condition and reference standard(s)	Invasive aspergillosis, as defined by EORTC criteria (Ascioglu 2002). They also used Chinese criteria, but not for these two‐by‐two tables Incorporation avoided? Not explicitly reported, so 'unclear' Acceptable reference standard? Yes: EORTC criteria
Flow and timing	Time interval NR Partial verification avoided? Yes Withdrawals explained? No Uninterpretable results reported? No
Comparative
No patients per category	4 proven, 29 probable, 34 possible, 27 no IA
Notes	No information on financial support reported Chinese language
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Yes
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Low	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Low	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	No
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	No
		High