Sun_Y 2010.

Study characteristics
Patient sampling	Enrolment not reported
Patient characteristics and setting	80 patients China Haematology department; patients with host factor of IFI and symptoms and signs of infection, plus: (1) unresponsive fever; or (2) imaging shows focus of infection in lung, head and paranasal sinus; or (3) other evidence of suspicious IPA infection Representative spectrum? No: seems to be highly selective
Index tests	Platelia test; cut‐off single sample 1.0 or consecutive samples 0.8
Target condition and reference standard(s)	Criteria of the Editorial Board of the Chinese Journal of Medicine Incorporation avoided? Unclear: not explicitly reported Acceptable reference standard? Unclear: Chinese criteria
Flow and timing	NR Partial verification avoided? Yes Withdrawals explained? Unclear: nothing reported on withdrawals Uninterpretable results reported? Yes: there were no uninterpretable results: N/A
Comparative
No patients per category	5 proven, 20 probable, 34 possible, 21 no IA
Notes	Not supported by Platelia
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Low	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low