Weisser 2005.
| Study characteristics | |||
| Patient sampling | Prospective; consecutive series of patients. Episode‐based analysis | ||
| Patient characteristics and setting | 161 participants Age ranged from 16 to 78 years 51% males Switzerland Adults undergoing autologous or allogeneic haematopoietic stem cell transplantation (HSCT) or receiving chemotherapy Inpatients; monitoring clinical course Representative spectrum? Yes: adults undergoing autologous or allogeneic HSCT or receiving chemotherapy |
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| Index tests | Platelia Aspergillus. Sera were tested twice weekly. 2 consecutives positive was considered positive. Cut‐off = 0.5 ODI | ||
| Target condition and reference standard(s) | Invasive aspergillosis, as defined by EORTC criteria Incorporation avoided? Not explicitly reported whether galactomannan results were excluded from EORTC criteria Acceptable reference standard? Yes: EORTC criteria |
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| Flow and timing | Timing not reported Partial verification avoided? Not clear Withdrawals explained? Not reported Uninterpretable results reported? Not reported |
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| Comparative | |||
| No patients per category | 20 proven or probable, 32 possible, 109 no IA | ||
| Notes | Sponsoring: Science Grant reported | ||
| Methodological quality | |||
| Item | Authors' judgement | Risk of bias | Applicability concerns |
| DOMAIN 1: Patient Selection | |||
| Was a consecutive or random sample of patients enrolled? | Yes | ||
| Was a case‐control design avoided? | Yes | ||
| Did the study avoid inappropriate exclusions? | Yes | ||
| Low | Low | ||
| DOMAIN 2: Index Test All tests | |||
| Were the index test results interpreted without knowledge of the results of the reference standard? | Unclear | ||
| If a threshold was used, was it pre‐specified? | Yes | ||
| Low | Low | ||
| DOMAIN 3: Reference Standard | |||
| Is the reference standards likely to correctly classify the target condition? | Yes | ||
| Were the reference standard results interpreted without knowledge of the results of the index tests? | Unclear | ||
| Unclear | Low | ||
| DOMAIN 4: Flow and Timing | |||
| Was there an appropriate interval between index test and reference standard? | Unclear | ||
| Did all patients receive the same reference standard? | Yes | ||
| Were all patients included in the analysis? | Unclear | ||
| Unclear | |||