White 2005.

Study characteristics
Patient sampling	Study design not clear
Patient characteristics and setting	105 participants No information about age or gender UK Patients considered to be at high risk for invasive fungal infection, no further details provided Representative spectrum? Patients considered to be at high risk, without further information
Index tests	Platelia Aspergillus. One positive is positive; no positive is negative; not reported how often samples were taken. Positive result: single sample above 1.5 ODI
Target condition and reference standard(s)	Invasive aspergillosis, as defined by EORTC criteria (no citation) Incorporation avoided? Not explicitly reported whether galactomannan results were excluded from EORTC criteria Acceptable reference standard? Yes: EORTC criteria (no citation)
Flow and timing	Timing not reported Uninterpretable results reported? No
Comparative
No patients per category	1 proven, 2 probable, 4 possible, 98 no IA
Notes	Sponsoring unclear; nothing reported
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Unclear
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Unclear
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Unclear	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low