Xu_P 2012.

Study characteristics
Patient sampling	113 patients with suspected lPA admitted in 'Department of Respiratory Medicine, Infectious Diseased, Kidney Disease Centre and ICU' were included in the study
Patient characteristics and setting	ICU patients
Index tests	Galactomannan antigen; threshold: two OD > 0.5 or one OD > 0.8.
Target condition and reference standard(s)	Invasive pulmonary aspergillosis, EORTC/MSG
Flow and timing	Difficult to extract due to Chinese language; time interval unclear. As reference standard was EORTC criteria and study used a one‐gate inclusion process, we assumed that all patients received the same reference standard. As there were no withdrawals or dropouts reported and the numbers in the 2x2 were the same as the numbers included, we assumed that all patients were included in the analyses.
Comparative
No patients per category	4 proven, 36 probable, 16 possible, 57 no IA
Notes	No information on conflicts of interest; Chinese language.
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Low
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Low	Low
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low