Zhang_X 2009.

Study characteristics
Patient sampling	No information provided
Patient characteristics and setting	88 children; China; no further info Little information provided; no inclusion criteria given; department not reported Representative spectrum? Unclear: no information provided except that they were children
Index tests	Platelia test, but not used as a standard care procedure. Cut‐off single sample 0.5
Target condition and reference standard(s)	Criteria of the Editorial Board of the Chinese Journal of Medicine Incorporation avoided? Yes, Platelia explicitly excluded from criteria Acceptable reference standard? Unclear: Chinese criteria and only 3 categories
Flow and timing	Time interval not reported Partial verification avoided? Yes Withdrawals explained? Not reported Uninterpretable results reported? Not reported
Comparative
No patients per category	14 proven/probable; 16 possible; 58 no IA
Notes	Sponsored by Platelia Chinese language
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Unclear
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Unclear
DOMAIN 2: Index Test All tests
Were the index test results interpreted without knowledge of the results of the reference standard?	Unclear
If a threshold was used, was it pre‐specified?	Yes
		Low	Low
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Unclear
Were the reference standard results interpreted without knowledge of the results of the index tests?	Unclear
		Unclear	Unclear
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Unclear
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Unclear
		Unclear

IFD: Invasive Fungal Disease; IFI: Invasive Fungal Infection; IPA: Invasive Pulmonary Aspergillosis; BAL: bronchoalveolar lavage; BMT: bone marrow transplantation; COI: conflict of interest; COPD: chronic obstructive pulmonary disease; CT: computerised tomography; ELISA: enzyme‐linked immunosorbent assay; EIA: enzyme immuno‐assay (equals ELISA); EORTC: European Organization for Research and Treatment of Cancer; GM: galactomannan; HSCT: haematopoietic stem cell transplantation; IA: invasive aspergillosis; ICU: intensive care unit; MSG: Mycoses Study Group; N/A: not applicable; NR: not reported; ODI: optical density index; PCR: polymerase chain reaction; ROC: receiver operating characteristic; SCT: stem cell transplantation; WBC: white blood cells.