Table 2.

Follicle Stimulating Hormone and Mean Lipid Levels in Postmenopausal Women, Kuopio Ischaemic Heart Disease Risk Factor Study (1998–2001).

	Unadjusteda	Model 1b			Model 2c			Model 3d
	Mean (SD)	Beta	SE	P	Beta	SE	P	Beta	SE	P
Total Cholesterol
FSH Q1	5.6 (0.7)		Ref			Ref			Ref
FSH Q2	5.8 (0.9)	0.014	0.008	0.09	0.014	0.008	0.10	0.014	0.008	0.08
FSH Q3	5.8 (0.9)	0.016	0.008	0.05	0.015	0.008	0.04	0.018	0.008	0.04
FSH Q4	5.9 (1.0)	0.025	0.008	0.004	0.025	0.009	0.003	0.025	0.009	0.004
p for trend	0.01			0.002			0.001			0.001
LDL-C
FSH Q1	3.6 (0.7)		Ref			Ref			Ref
FSH Q2	3.8 (1.0)	0.013	0.013	0.29	0.014	0.013	0.26	0.015	0.013	0.23
FSH Q3	3.8 (0.9)	0.022	0.013	0.09	0.025	0.013	0.05	0.026	0.013	0.05
FSH Q4	3.9 (1.0)	0.031	0.013	0.02	0.035	0.013	0.01	0.035	0.013	0.01
p for trend	0.15			0.01			0.01			0.007
HDL-C
FSH Q1	1.3 (0.3)		Ref			Ref			Ref
FSH Q2	1.3 (0.3)	0.021	0.011	0.06	0.018	0.011	0.12	0.018	0.011	0.12
FSH Q3	1.4 (0.3)	0.021	0.012	0.07	0.019	0.012	0.11	0.019	0.012	0.11
FSH Q4	1.4 (0.3)	0.025	0.012	0.04	0.018	0.012	0.13	0.018	0.012	0.13
p for trend	<0.001			0.02			0.06			0.06
Triglycerides
FSH Q1	1.4 (0.7)		Ref			Ref			Ref
FSH Q2	1.3 (0.8)	0.015	0.021	0.47	0.025	0.02	0.23	0.021	0.020	0.29
FSH Q3	1.2 (0.5)	0.010	0.022	0.66	0.021	0.021	0.49	0.014	0.021	0.50
FSH Q4	1.2 (0.6)	0.014	0.022	0.51	0.021	0.022	0.09	0.037	0.021	0.08
p for trend	0.01			0.67			0.21			0.17

FSH: follicle stimulating hormone, Q: quartile, SE: standard error;

^aUnadjusted, untransformed mean total cholesterol (mmol/L), low-density lipoprotein cholesterol (LDL-C, mmol/L), high-density lipoprotein-cholesterol (HDL-C, mmol/L), and triglycerides (mmol/l). P-value from ANOVA

^bLipid levels log transformed to improve normality in all regression models. Model 1 adjusted for age (continuous), year of study entry (continuous), estradiol (quartiles), testosterone (quartiles), sex-hormone binding globulin (quartiles), age at menarche (above and below median), last menstruation age (above and below median), duration of oral contraceptive use (above and below median), duration of hormone therapy use (above and below median), history of hysterectomy (yes, no), history of oophorectomy (yes, no).

^cModel 2 adjusted for model 1 covariates and systolic blood pressure (continuous), diastolic blood pressure (continuous), smoking status (never, past, current + pack-years above median; current + pack-years below median), physical activity (quartiles), body mass index (continuous), and waist-to-hip ratio (continuous).

^dModel 3 adjusted for model 2 covariates and use of lipid lowering medication (yes, no)