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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Liver Int. 2019 Apr 2;39(5):788–801. doi: 10.1111/liv.14091

Figure 2: Surgical, Donor, and Recipient factors that contribute to risk of IRI.

Figure 2:

(1) Risks of IRI inherent to liver transplantation include: organwide ischemia during clamping and resection of donor organ, cold storage, re-anastomosis and circulation of widespread inflammatory factors, increased ischemic time. (2) Donor Liver risk factors can increase the severity of IRI: small allograft, advanced age, especially age >70, donor fatty liver, especially macrosteatosis > 30%, cause of donor death, NHBBD donor, use of marginal organs due to donor scarcity. (3) Recipient risk factors can further increase the severity of IRI: cirrhosis or hepatic fibrosis induced coagulopathy, nutritional coagulopathy, portal vein or hepatic artery thrombosis, altered VWF:ADAMTS13 ratio, history of NASH.