Table 2:
De novo Donor Specific Antibody Characteristics at the time of Detection
| All N=113 |
Center A N=28 |
Center B N=35 |
Center C N=50 |
P-value | |
|---|---|---|---|---|---|
| Time post-transplant to dnDSA detection median (IQR) year | 1.1(0.6–2.8) | 1.0(0.8–3.8) | 0.9(0.6–1.3) | 2.1(0.5–5.1) | P<0.01 |
| Class I only n(%) | 21(18.5) | 3(10.7) | 7(20.0) | 11(22.0) | P=0.34 |
| Class II only n(%) | 61(54.0) | 18(64.3) | 21(60.0) | 22(44.0) | |
| Class I + Class II n(%) | 31(27.4) | 7(25.0) | 7(20.0) | 17(34.0) | |
| Dominant DSA Median MFI (IQR) | 9592(3362–14923) | 7537(2652–12343) | 7707 (4052–11623) | 12751(3540–19233) | P=0.05 |
| Number of DSA Specificities Median (IQR) | 1(1–2) | 1(1–2) | 1(1–2) | 2(1–3) | P=0.27 |
| IgG 3* n(%) | 29(25.7) | 12(42.9) | 4(11.4) | 13(26.0) | P=0.02 |
| IgG 4* n(%) | 17(15.0) | 4(14.3) | 3(8.6) | 10(20.0) | P=0.35 |
| C1q* n(%) | 12(10.6) | 6(21.4) | 4(11.4) | 2(4.0) | P=0.06 |
*
based on MFI of > 1000.