Table 3:

Univariate and Multivariate Predictors of Allograft Loss

	Univariate		Stepwise Model
Variable	HR	p	HR	p
Age of Recipient	1.0 (1.0, 1.0)	0.45
Race	0.9 (0.4, 2.0)	0.86
Deceased donor	0.9 (0.4, 1.9)	0.79
Steroid containing immunosuppression	1.8 (0.7, 4.9)	0.22
History of Nonadherence	3.2 (1.5, 7.0)	0.002	6.5 (2.6, 15.9)	<0.0001
Prior Kidney Transplant	0.8 (0.3, 2.1)	0.60
Viral Infection requiring immunosuppression reduction	2.1 (0.9, 4.6)	0.07	5.3 (2.1, 13.5)	0.0004
BK nephropathy prior to DSA	1.2 (0.4, 4.1)	0.75
C1q (MFI >1000)	5.9 (2.3, 15.6)	0
IgG 3 (MFI>1000)	3.2 (1.5, 7.0)	0.002	3.8 (1.5, 9.3)	0.0039
IgG 4 (MFI>1000)	2.1 (0.8, 5.7)	0.14
Dominant MFI (Log)	1.4 (0.46, 4)	0.57
Number of DSA specificities	1.1 (0.9, 1.3)	0.35
Anti-class I DSA only	0.7 (0.2, 2.1)	0.52
Anti-class II DSA only	0.7 (0.3, 1.5)	0.36
Both Anti class I and II DSA	2.0 (0.9, 4.3)	0.10
Center
Center B	-
Center A	1.1 (0.4, 2.8)	0.86
Center C	0.6 (0.2, 1.4)	0.22
Time to dnDSA (years post-transplant)	1.2 (1.1, 1.3)	0.004	1.2 (1.0, 1.3)	0.01
C-stat	NA	NA	0.80

The interaction term between C1q and IgG subclasses was nonsignificant p> 0.05.