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. 2019 Apr 25;9:6539. doi: 10.1038/s41598-019-42990-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DYRK1A expression and kinase activity are necessary for maintaining basal 53BP1 expression. (A) Immunoblot for 53BP1, DYRK1A and GAPDH expression in either WT, DYRK1A KO or 1 µM harmine treated WT cells at 0, 1, 4, and 8 hrs following 4 Gy of IR. Bands were cropped from portions of the same blot. (Full molecular weight range seen in Suppl. Fig. S3C). (B) Quantification of DYRK1A expression from three independent experiments outlined in 4a (student’s t-test). (C) Representative immunofluorescent images of DAPI, DYRK1A and RNF169 staining 1 hour post- 4 Gy of Irradiation.