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. 2019 Apr 25;9:6569. doi: 10.1038/s41598-019-42982-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dependent changes in the best corrected visual acuity (BCVA; A), central foveal thickness (CFT; B), macular nonperfusion area (NPA; C), and total NPA (D) in patients treated with ranibizumab injections for macular edema caused by branch retinal vein occlusion (BRVO). At month 24, BCVA (logarithm of the minimum angle of resolution units) has improved while CFT has significantly decreased (P < 0.001 vs. baseline measurements for both). In contrast, the macular NPA in the superficial capillary plexus (dotted line) and deep capillary plexus (solid line) has not changed (C). The total NPA has significantly increased in the overall patient sample (circle) and in the subgroup of patients with major BRVO (square), whereas it has not changed for patients with macular BRVO (triangle; D).