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. 2019 Apr 25;9:6569. doi: 10.1038/s41598-019-42982-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enlargement of retinal nonperfusion areas (NPAs) according to the anatomical position of the retinal vessels at affected arteriovenous crossings in eyes with branch retinal vein occlusion (BRVO). Ultrawide-field fluorescein angiography showing an arterial overcrossing pattern (A,B) and a venous overcrossing pattern (C,D). (A,C) Images at baseline. (B,D) Images at month 12. Images inset in panels A, and C show enlargements of the affected crossing sites. In images for a representative case of venous overcrossing (C,D), a marked increase in NPA, especially in the periphery, can be observed. In contrast, NPA enlargement is unremarkable in representative images for a case of arterial overcrossing (A,B).