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. 2019 Apr 25;9:6403. doi: 10.1038/s41598-019-42833-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the time course and magnitude of LTP between WT and SNAP-25b-deficient (MT) mice at 4 and 8 weeks of age. (a) MT male mice exhibited a significant deficit in the magnitude of LTP at 4 weeks of age compared to WT mice (****p < 0.0001, Student’s t-test, WT; n = 8, MT; n = 11). (b) MT Female mice exhibited a significant deficit in the maintenance of LTP as well at 4 weeks of age (****p < 0.0001, Student’s t-test, WT; n = 7, MT; n = 7). (c) To assess any developmental changes associated with age, LTP was assessed in MT males and females at 8 weeks of age and again MT male mice exhibited a significant deficit in the magnitude of LTP (****p < 0.0001, Student’s t-test, WT; n = 7, MT; n = 16), similarly (d) MT female mice exhibited a significant deficit in the magnitude of LTP at 8 weeks of age (****p < 0.0001, Student’s t-test, WT; n = 9, MT; n = 14) as well, demonstrating that SNAP-25b promotes larger LTP at Schaffer collateral-CA1 synapses. (e) Illustration showing the experimental arrangement for recording hippocampal Schaffer collateral-CA1 synaptic LTP in coronal hippocampal slices. (f) Comparison of the means of fEPSP slopes in the last 5 minutes of LTP recordings at all ages. MT mice exhibited deficit in the magnitude LTP all ages, but WT male and female mice differ from each other at 4 and 8 weeks as well. WT female mice exhibited a significantly reduced magnitude of LTP at 4 weeks of age compared to WT males but a significantly larger magnitude of LTP at 8 weeks of age (****p < 0.0001, one-way ANOVA followed by Bonferroni’s multiple comparison test). All error bars represent ± s.e.m.