Table 1.

Transcriptional analysis of limb progenitors subjected to gain-of-function and loss-of-function of either Uhrf1 or Uhrf2 genes

	cUhrf1	shUhrf1	cUhrf2	shUhrf2
Differentiation markers
Scx	1.02 ± 0.11	0.59 ± 0.06***	1.17 ± 0.20	0.50 ± 0.09***
Sox9	0.59 ± 0.07***	0.93 ± 0.09	0.59 ± 0.08***	0.80 ± 0.15
Senescence marker
p21	6.18 ± 1.98*	0.56 ± 0.07***	2.36 ± 0.35**	0.38 ± 0.08***
Cell death markers
Bcl2	1.24 ± 0.10	1.12 ± 0.06	0.89 ± 0.07	1.01 ± 0.14
Bak1	2.44 ± 0.51**	0.59 ± 0.03***	1.80 ± 0.34*	0.80 ± 0.10
Bid	1.45 ± 0.21	0.85 ± 0.06	1.24 ± 0.15	0.92 ± 0.15
Bim	0.99 ± 0.04	1.24 ± 0.12	0.91 ± 0.19	0.98 ± 0.12
Bmf	1.72 ± 0.31*	0.94 ± 0.08	1.02 ± 0.13	0.89 ± 0.14

Uhrf1	10.33 ± 2.88**	0.44 ± 0.03***	1.98 ± 0.35*	0.69 ± 0.07***
Uhrf2	1.26 ± 0.12	0.95 ± 0.05	10.31 ± 2.53**	0.50 ± 0.04***

The panel of genes analyzed included markers for skeletogenic differentiation, senescence, and apoptosis

***p < 0.001; **p < 0.01; *p < 0.05 treated versus control

Statistic significant values are highlighted in bold