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Overview of Grp94 and BiP conformations. Mutation sites that disrupt binding between HtpG and DnaK are shown in red spheres. A, these sites are exposed on the Grp94 open conformation (ADP; Protein Data Bank (PDB) code 2O1V) and the closed conformation (ATP; PDB code 5ULS). B, in contrast, these sites are mostly exposed in the BiP ADP conformation (modeled from PDB code 2KHO) and blocked in the ATP conformation (PDB code 5E84).
