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Structures of S1QELs and their derivatives studied in the present study. S1QEL1.1, S1QEL1.5, S1QEL2.1, and S1QEL2.3 were reported in Ref. 24. S1QEL1.1_D1, S1QEL1.1_D2, S1QEL1.1_D3, and S1QEL1.5_D1 were derived from corresponding parent S1QELs. Photolabile [125I]S1QEL1.1_PD1 and [125I]S1QEL1.1_PD2 were used for photoaffinity labeling experiments.
