Supplementary Table 2.

Inhibition of formation of multinucleated giant cells by neutralizing antibodies specific for IL-3, IL-5, IL-7, and GM-CSF

	Fusion index (%) a
Antibodyb	IL-3 (5 ng/ml)	IL-5 (1 ng/ml)	IL-7 (20 ng/ml)	GM-CSF (1 ng/ml)
Polyclonal mouse IgG	63.8 ± 1.2	62.3 ± 3.6	66.2 ± 5.4	67.7 ± 6.0
Anti-IL-3	7.3 ± 1.6	-	-	-
Anti-IL-5	-	3.8 ± 1.8	-	-
Anti-IL-7	-	-	5.5 ± 5.8	-
Anti-GM-CSF	-	-	-	4.0 ± 1.3

^aFusion indices were calculated using the formula given in the Methods section. Each value is the mean ± SD of three independent experiments using TRAP-positive cells induced from monocytes of three individuals. ^bConcentrations of cytokines: polyclonal mouse IgG, 10 mg/ml; anti-IL-3, 10 mg/ml; anti-IL-5, 5 mg/ml; anti-IL-7, 10 mg/ml, anti-GM-CSF, 2 mg/ml. - = not examined; GM-CSF = granulocyte/macrophage-colony-stimulating factor; IL = interleukin.