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. 2019 Mar 18;23(5):3166–3177. doi: 10.1111/jcmm.14171

Figure 2.

Figure 2

Effect of overexpression or suppression of miR‐7 on chemosensitivity of 5‐fluorouracil (5‐FU)‐resistant BC cells. (A) Expressions of miR‐7 in BC cells; (B), cell growth curve of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor; (C), IC50 of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor in each group; (D), colon formation images of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor; (E), colon formation rate of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor in each group; (F), cell apoptosis of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor by FCM; (G), cell apoptosis rate of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor in each group; (H), western blot on apoptosis related factors of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor; (I), expressions of apoptosis related factors of 5‐FU‐resistant BC cells after being transfected with miR‐7 mimic or miR‐7 inhibitor; *, compared with Blank group, P < 0.05; BC, breast cancer; IC50, half maximal inhibitory concentration