Figure 4.

Regulation on miR‐7 and CDR1as can influence the chemosensitivity of 5‐fluorouracil (5‐FU)‐resistant breast cancer (BC) cells. (A) Cell growth curve of 5‐FU‐resistant BC cells; (B), IC50 of 5‐FU‐resistant BC cells; (C), colon formation assay on 5‐FU‐resistant BC cells after regulation on miR‐7 and CDR1as; (D), colon formation rate of 5‐FU‐resistant BC cells; (E), cell apoptosis of 5‐FU‐resistant BC cells as detected by FCM; (F), cell apoptosis rate of 5‐FU‐resistant BC cells; (G), western blot on cell apoptosis related factors in 5‐FU‐resistant BC cells; (H), expressions of cell apoptosis related factors in 5‐FU‐resistant BC cells; #, comparisons among groups, P < 0.05