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. 2019 Feb 15;23(5):3357–3368. doi: 10.1111/jcmm.14226

Figure 6.

Figure 6

Proposed mechanism of ligustilide (LIG) interference with osteoarthritis chondrocyte apoptosis. LIG inhibited chondrocyte apoptosis and ameliorated cartilage degeneration via the JNK and p38 mitogen‐activated protein kinas (MAPK) signalling pathways, leading to the down‐regulation of inducible nitric oxide synthase (iNOS) and p‐activating transcription factor 2 (ATF2) expression