FIG. 4.

Effect of formoterol on mitochondrial proteins in the injury site of mice subjected to spinal cord injury (SCI). Mice underwent moderate SCI using an 80 Kdyn force-controlled impactor induced contusion model followed by daily intraperitoneal administration of vehicle or formoterol (0.1 mg/kg) beginning 1 h post-injury. Subsets of mice were euthanized three days (A), seven days (B), and 15 days (C) post-SCI and the injury site extracted and analyzed for protein. Data represent 5–6 mice per group and are expressed as mean ± standard error of the mean. For each protein, different superscripts are indicative of statistically significant differences in expression (p< 0.05 by one-way analysis of variance followed by Tukey post hoc test). Bars with the same superscripts are not significantly different. Nrf2, nuclear respiratory factor 2; PGC-1α, peroxisomal proliferator γ coactivator-1α; TFAM, mitochondrial transcription factor A; ATP, adenosine triphosphate; NDUFS1, nicotinamide adenine dinucleotide:ubiquinone oxidoreductase core subunit S1.