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. 2019 Apr 25;21(6):516–532. doi: 10.1016/j.neo.2019.02.004

Figure 5.

Figure 5

Functional role of ERO1β on OS cell survival against chemotherapy.(A) and (B) Total RNAs extracted from siRNA expressing OS cells with and without Tm treatment were quantitated for expression levels of ERO1β mRNA levels by qPCR analysis after normalizing to 18s rRNA Bar mean ± SE of 3 independent experiments. (C) Quantitation of caspase 3 activation in OS cells following ERO1β down-regulation in the presence or absence of cisplatin. Graph represents mean ± SE of 3 independent experiments and compared to their respective si-ctrl cisplatin treated samples for statistical analysis *P < .05, **P < .01. (D) Representative immunofluorescence images of cleaved caspase-3 positive cells in siControl and siERO1β expressing OS cells following treatment with cisplatin.