Table 3.
Association Between ATF6α and Characteristics of Osteosarcoma Patients (n = 40)
| Tumor Site | Overall n = 40 |
Living n = 27 |
Died n = 13 |
P Value for Survival Differences† |
|---|---|---|---|---|
| Femur | 21 | 15 | 6 | n.s. |
| Humerus | 7 | 5 | 2 | |
| Tibia | 6 | 5 | 1 | |
| Other limb | 3 | 1 | 2 | |
| Axial | 3 | 1 | 2 | |
| Overall Metastases | 19 | 7 | 12 | .0001 |
| Metastases @ diagnoses | 10 | 4 | 6 | .04 |
| % necrosis⁎ (Mean±S.D.) |
67.8+ 37.7 | 76.7 + 31.0 | 43.7 + 45.0 | .02 |
| Overall survival (months, Median ±S.D.) | 52.7 + 28.4 | 62.8 + 28.1 | 31.8 + 14.6 | <.0001 |
| Time to relapse (months) | 49.6 + 27.5 | 58.6 + 27.9 | 30.8 + 14.7 | .0002 |
| ATF6α nuclear | ||||
| Low | 30 | 24 | 6 | .003 |
| High | 10 | 3 | 7 |
†
Wilcoxon rank sum test.
⁎
n = 37, alive = 27, died = 10.