Table 6.
Association Between ATF6α (N) Levels and Models of Progression-Free Survival Among Osteosarcoma Patients (n = 40)
| Characteristics | Univariate Analysis |
Multivariate Analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| ATF6α Low (0) or High (1) | 6.690 (2.502, 17.888) | .0002 | 4.912 (1.735, 13.904) | |
| Metastasis at diagnosis | 5.029 (1.910, 13.239) | .001 | 3.283 (1.180, 9.138) | .0001 |
| ATF6α Low (0) or High (1) | 9.182 (2.926, 28.814) | |||
| Percentage of necrosis⁎ | 0.988 (0.975, 1.001) | .071 | 0.985 (0.972, 0.999) | .0002 |
| ATF6α Low (0) or High (1) | 5.767 (1.654, 20.111) | |||
| Metastasis at diagnosis | 5.316 (1.484, 19.044) | |||
| Percentage of necrosis⁎ | 0.980 (0.943, 0.996) | <.0001 | ||
Including ATF6α in the analysis leads to a 7.6-fold improvement in the model of PFS.
⁎
Results and models that include the percentage of necrosis are based on the data of n = 37.