Table 1.

Single Subject Hypotheses. This table lists the hypotheses, framed by individual participants, tested in single-subject, natural experiments during the study.

Participant ID(s)	Hypothesis
1–18	Our lipids may vary significantly within-a-day.
1–12	Our lipids may vary significantly across mornings in the fasted state.
1, 17	My blood cholesterol and triglycerides may show ultradian and daily rhythms.
2	My lipids may cross a risk category within a day.
3	My post-prandial triglyceride rise may vary predictably based on the kind of food I eat.
4	My cholesterol and triglycerides may show ultradian rhythms that correlate with those in my electrogastrogram power or body temperature.
5	I can use my post-prandial triglyceride responses to create a “personal lipidemic index” comparable to a glycemic index of different foods.
6, 7	My subjectively and/or HRV-estimated stress may correlate with my cholesterol or triglyceride levels within a day.
7	Taking repeated multi-time-point “baselines” across different days may reveal stereotyped daily variability in my lipids.
8	Switching to a plant-based vegan diet may change my lipid levels within two weeks.
9	Natural variability in my lipids by time of morning may cause me to cross a risk category.
10	My daily fasting lipids, and 2-hour lipid profile may change in range or shape during very low, medium low, and moderate carb diets.
11, 14	Running may have a short term (before versus directly after a 30, 60 or 90-minute run) effect on my lipids.
11	A vegan diet may lower my total cholesterol and triglycerides over three months.
12	Tracking my lipids may be an effective encouragement for me to lose weight.
13, 16	Psychological and physical stressors (as measured subjectively and by HRV) may have distinct, measurable effects on my lipids.
15	My post-prandial triglyceride and cholesterol elevation may differ between days in which I eat three meals, and days in which I eat only one meal.
17	Changing the macro-nutrient composition of my diet for two-week increments may affect my post-prandial and daily fasted lipid levels.
19	I am interested in if my lipids and PT/INR (a measure of blood coagulation) co-vary, and if this influences the effectiveness of at home blood testing for me. Perhaps if I clot too quickly the test is ineffective.
19	I am interested in if my lipids change from before to after a) a long walk or b) a tai chi class.
20	My fasting lipids may vary predictably across my menstrual cycle.
21	I hypothesize that marathon training over two months will impact my cholesterol, and that my cholesterol may also differently from pre-to post run depending on run intensity.