Comparison 24. Topical calcineurin inhibitors: pimecrolimus 1% cream versus vehicle.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Primary: investigator‐rated good/excellent control of symptoms pimecrolimus cream vs vehicle	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Primary: investigator‐rated clear or almost clear pimecrolimus cream vs vehicle 3 weeks	1	294	Risk Ratio (M‐H, Random, 95% CI)	1.53 [0.99, 2.36]
1.2 Primary: investigator‐rated clear or almost clear pimecrolimus cream vs vehicle 6 weeks	1	652	Risk Ratio (M‐H, Random, 95% CI)	1.28 [0.99, 1.66]
1.3 Primary: investigator‐rated clear or almost clear pimecrolimus cream vs vehicle 3 weeks irritant hand eczema	1	185	Risk Ratio (M‐H, Random, 95% CI)	1.7 [0.93, 3.10]
1.4 Primary: investigator‐rated clear or almost clear pimecrolimus cream vs vehicle 3 weeks allergic hand eczema	1	49	Risk Ratio (M‐H, Random, 95% CI)	1.33 [0.30, 5.96]
1.5 Primary: investigator‐rated clear or almost clear pimecrolimus cream vs vehicle 3 weeks endogenous hand eczema	1	134	Risk Ratio (M‐H, Random, 95% CI)	1.32 [0.75, 2.33]
2 Primary: adverse events	3		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected
2.1 Discontinuation because of adverse event	2		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.2 Application site reaction	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.3 At least 1 adverse event	2		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.4 Serious adverse event (not related to study)	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.5 Treatment‐related adverse event	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.6 Erythema or irritation	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.7 Itching	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.8 Warmth, stinging, burning	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.9 Herpes simplex virus infection	1		Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
3 Secondary: participant‐rated reduction in severity pruritus relief between pimecrolimus 1% and vehicle	1		Risk Ratio (M‐H, Random, 95% CI)	Totals not selected