Draelos 2000.

Methods	Randomised controlled trial with a within‐participant design This study was conducted at a single centre in North Carolina, USA The study was double‐blind; an intention‐to‐treat analysis was not carried out
Participants	80 participants between the ages of newborn and 80 years with the following dermatological conditions: household hand dermatitis (n = 21), occupational hand dermatitis (n = 18), latex glove irritant contact dermatitis (n = 9), diaper dermatitis (n = 5), cutaneous wounds (n = 17), and allergic contact dermatitis (n = 10) Dropouts: 7 Exclusion criteria of the trial Use of any prescription skin medications or other treatments at the study site for a 2‐week washout period before initiation of the study Use of topical corticosteroid creams or oral corticosteroids
Interventions	Intervention • The study hydrogel barrier/repair cream (Hydron) for 4 weeks in 80 participants Control • Control moisturising cream (Eucerin, Beiersdorf, Germany) for 4 weeks in 80 participants
Outcomes	Primary outcomes of the trial Not stated Other outcomes Participant‐rated: overall skin appearance and feel based on a questionnaire in week 2 and week 4 Investigator‐rated improvement in erythema, roughness, desquamation, serum crusting (where appropriate), and inflammation on an ordinal rating system (–2, noticeably worse; –1, worse; 0, no change; 1, better; 2, noticeably better) Photographs
Notes	RCT on different diseases, mostly on hand eczema. Number of participants with hand eczema and results for participants with this condition are impossible to reconstruct. We were unable to obtain separate data from the study investigator