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. 2019 Apr 26;2019(4):CD004055. doi: 10.1002/14651858.CD004055.pub2

Grundmann 1999.

Methods Randomised within‐participant study
This study probably was conducted at a single centre in Germany
The study was not blinded, and all participants were included in the analyses
Participants 12 patients with severe plaque psoriasis (n = 4), severe atopic dermatitis (n = 4), or severe hyperkeratotic eczema (n = 4)
Dropouts: none
Inclusion criteria
  • Resistance to topical therapy

  • Severity score of at least 16 points in self‐created scoring system (see outcomes)

Interventions Intervention
• PUVA cream therapy with 8‐methoxypsoralen (8‐MOP) 4 times a week
• PUVA bath therapy 4 times a week
Participants were followed up for an additional 8 weeks after the end of treatment. Exact duration of treatment and number of treatments were not clear
Outcomes Primary outcomes of the trial
Not defined
Other outcomes
  • Investigator‐rated severity score for each item on each hand and/or foot for erythema, scaling, infiltration, pustulation, and hyperkeratosis from 0 to 4 (0 = no symptoms, 4 = maximum), resulting in a total score of 20 every week

  • Investigator‐rated improvement in total score (0 to 4 excellent, 5 to 8 good) every week

Notes RCT on different dermatoses among hand eczema. We were unable to reconstruct the results from the paper among participants with hand eczema, and we were unsuccessful in locating the study authors