IRCT201112018263N1.

Methods	Double‐blind randomised parallel‐group design, placebo‐controlled
Participants	70 patients with moderate to severe hand eczema, aged 12 to 70 years Exclusion criteria Treatment with systemic steroid less than 1 month before the trial Treatment with topical steroid and antihistamines at the time of presentation Pregnancy Lactation Younger than 12 years
Interventions	Intervention • Doxepine 5% cream applied twice daily for 8 days and clobetasol 0.05% applied twice daily for 8 days Control intervention • Placebo and clobetasol 0.05% applied twice daily for 8 days
Outcomes	Primary outcome of the trial Reduction or improvement in hand eczema before and 8 days after treatment measured with the hand eczema severity index (HECSI) Secondary outcomes of the trial Adverse events 8 days after initiation of treatment
Notes	Recruitment completed Study authors contacted for additional information on 20 February 2014, but they remained unresponsive Sponsor: Shahid Sadoughi University of Medical Sciences, Yazd