IRCT201212303734N2.

Methods	Randomised double‐blind parallel‐group study
Participants	108 patients with hand eczema confirmed by a dermatologist Inclusion criteria 18 to 75 years of age Eager to participate in the trial With hand eczema confirmed by a dermatologist Exclusion criteria Pregnancy and lactation Application of topical drugs during previous 2 weeks Systemic therapies such as corticosteroids Immunosuppressive drugs and antibiotics during the past 4 weeks Localised hand infection History of allergic reaction to study medication
Interventions	Intervention • Anti Dry cream (contains Aloe Vera essence, Geranium essence, Lavander essence, respectively, with ratio of 50:1:15 in vanishing cream), 1 fingertip unit (0.5 grams) for 10 × 10 cm², twice daily for 2 weeks • Fluocinolone acetonide cream 0.025%, twice daily, for 2 weeks
Outcomes	Primary outcome of the trial Change in signs and symptoms of hand eczema on day 14 compared to day 0, measured by a questionnaire containing clinical signs and symptoms: erythema, scaling, lichenification/hyperkeratosis, oedema, vesicle, fissure, pruritus, and pain Secondary outcomes of the trial Adverse events Change in pruritus, erythema and scaling, bullae
Notes	Sponsor: Barij Essence Herbal Medicine Research Center Current status: recruiting