IRCT2014012916412N1.

Trial name or title	Effects of pumpkin (Moschata cucurbita) ointment on chronic hand eczema Official title: Effect of topical pumpkin, traditional medicine products, on the chronic hand eczema
Methods	Randomised double‐blind parallel‐group placebo‐controlled study
Participants	60 patients with moderate chronic hand eczema Inclusion criteria Interested in participating in the study 18 to 60 years of age Mild to moderate chronic hand eczema according to criteria HECSI (occupational dermatitis, atopic dermatitis, contact dermatitis irritant) Non‐use of oral corticosteroids during the last 2 months Lack of local immunosuppressors within 4 weeks before treatment Lack of pregnancy and lactation No history of contact dermatitis to prescription drugs Lack of local infection No obsessive and excessive washing with water and detergent Absence of immunosuppressive disease Exclusion criteria History of allergy to drugs Use of oral or topical corticosteroids during the 4 weeks before the study Local infection at the site of the lesion eczema Women during pregnancy or lactation Severe obsessive washing Physical or mental disorders that interfere with participation in the study
Interventions	Intervention • Betamethasone ointment twice a day for 1 month • Almond ointment twice a day for 1 month • Eucerin ointment twice a day for 1 month • Pumpkin ointment twice a day for 1 month
Outcomes	Primary outcome of the trial Hand Eczema Severity Index Dermatology Life Quality Index Secondary outcomes of the trial Skin reactions Recovery rates
Starting date	September 2014
Contact information	Alemeh Khademi Imam Khomeini Hospital Islamic Republic of Iran Skin Clinic, Imam Khomeini Hospital, Keshavarz bulv  Tehran  00982166595911  00989171132340 00  alemehkhadi@gmail.com
Notes	Sponsor: Vice Chancellor for Research at Tehran University School of Traditional Medicine