COMMAND‐1 2015a2

Methods	For characteristics see COMMAND‐1 2015a1
Participants
Interventions
Outcomes
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Low risk	The trial used interactive voice‐response system
Blinding of participants and personnel (performance bias) All outcomes	High risk	The participants were only blinded until week 24
Blinding of outcome assessment (detection bias) All outcomes	High risk	The sponsors, who performed the analyses, were only blinded until week 12
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	More than 5% dropped out
Selective reporting (reporting bias)	Low risk	All outcomes stated in the protocol were assessed
Vested‐interest bias	High risk	The trial was funded by Bristol‐Myers Squibb.
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias