| Methods | For characteristics see Dauphine 2015a2 | |
| Participants | ||
| Interventions | ||
| Outcomes | ||
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Computer‐generated randomisation |
| Allocation concealment (selection bias) | Unclear risk | Not described |
| Blinding of participants and personnel (performance bias) All outcomes | High risk | Unblinded |
| Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unblinded |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | There were above 5 % drop outs and it was unclear how the trial handLed the missing participants |
| Selective reporting (reporting bias) | Low risk | All outcomes stated in the protocol were reported on: NCT01220947 |
| Vested‐interest bias | High risk | The trial was funded by F. Hoffmann‐La Roche Ltd |
| Other bias | Low risk | The trial appeared to be free of other components that could put it at risk of bias |
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