Foster 2015a2

Methods	For characteristics see Foster 2015a2
Participants
Interventions
Outcomes
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Low risk	An Interactive Web Response System was used
Blinding of participants and personnel (performance bias) All outcomes	High risk	Described as open‐label
Blinding of outcome assessment (detection bias) All outcomes	High risk	Described as open‐label
Incomplete outcome data (attrition bias) All outcomes	Low risk	Only 5 participants dropped out
Selective reporting (reporting bias)	High risk	SVR 24 was not reported as described in the prepublished protocol (NCT02220998 and supplementary material at NEJM.org)
Vested‐interest bias	High risk	The trial was funded by a company that might have an interest in a given result (Gilead Sciences)
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias