GlaxoSmithKline 2014

Methods	Randomised clinical trial
Participants	37 adult participants (18‐60 years) chronically infected with HCV (genotype 1 (1a or 1b), genotype 2 or genotype 4.
Interventions	Experimental group: oral GSK2878175 10 mg, 30 mg or 60 mg for 2 days. Control group: placebo.
Outcomes	Safety, pharmacokinetics, HCV RNA.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Low risk	The participants and personnel were blinded
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	The trial was described as being blinded but it was unclear how the blinding of outcome assessors was performed
Incomplete outcome data (attrition bias) All outcomes	Low risk	< 5% dropped out
Selective reporting (reporting bias)	Unclear risk	No protocol could be obtained
Vested‐interest bias	High risk	The trial was sponsored by Glaxo Smith Kline
Other bias	Low risk	The trial appeared to be free of other components that could put it at risk of bias