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. 2019 Mar 15;38(9):e101140. doi: 10.15252/embj.2018101140

Figure EV1. Structure of the SecA‐SecY complex.

Figure EV1

  1. Side view with a translocating polypeptide (black line) modeled into the crystal structure (PDB 3DIN). SecA is in pink, SecY in blue, and SecG and SecE in green. The lateral gate of the SecY channel is in the front. The two‐helix finger (THF) of SecA is highlighted in red and a conserved Tyr residue at its tip shown in yellow in stick presentation.
  2. View from the cytosol. SecA's domains are shown in different colors, and ATP is shown in its binding site. The red star indicates the position of the translocating polypeptide.
  3. Clamp conformational change. The PPXD from the crystal structure of SecA with an open clamp conformation (PDB 1M74) aligned to SecA in the closed conformation. NBD2 is in blue. The closed PPXD is in yellow and the open conformation is in orange. The arrow indicates the PPXD movement.