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. 2019 Mar 19;23(5):3345–3356. doi: 10.1111/jcmm.14225

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© 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Early growth response 1 (Egr1) is up‐regulated in diabetic retinopathy tissues and human retinal vascular endothelial cells (HRVECs) under high‐glucose (HG) conditions. A, Heat map of differentially expressed mRNAs in the retinas of normal and streptozotocin (STZ)‐induced diabetic rats. B, The diagram shows expression of Egr1 in retinal tissues of normal and STZ‐induced diabetic rats measured by qRT‐PCR (n = 20; *P < 0.05). C, The mRNA expression of Egr1 in HRVECs under basic and HG conditions for 2 wk (*P < 0.05 compared with Basic group). D, Protein expression of Egr1 in HRVECs cultured in HG conditions measured by Western blot. E, Quantification analysis of Egr1 protein expression according to Figure 1D (**P < 0.01 compared with Basic group).