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. 2019 Mar 18;38(9):e100526. doi: 10.15252/embj.2018100526

Figure EV4. Direct targets of human Gata6 predicted by ChIP‐Atlas.

Figure EV4

Human Gata6 ChIP‐Seq datasets were interrogated using the “Target Genes” module of ChIP‐Atlas (Oki et al, 2018 and http://chip-atlas.org). The included datasets were obtained from human ES cell‐derived mesendodermal cells (GEO accession numbers: GSM1505658, GSM1505660, GSM1505662) and human adenocarcinoma cell lines from stomach (AGS (GSM1250897, GSM1255511), HuG1‐N (GSM1255513), YCC‐3 (GSM1250893)), colon (Caco‐2 (GSM575226, GSM575227), LS‐174T (GSM1197320, GSM1197321, GSM1197322), and pancreas (PA‐TU‐8988S (GSM1151694)). A Gata6‐binding peak was found within 10 kb from the transcription start in at least two different datasets for eight genes of the MMR pathway (Msh3, Rfc2, Pold4, Ssbp1, Pold3, Exo1, Rfc1, and Mlh3). The heat‐map represents MACS2 binding scores for the MMR genes in the corresponding datasets.