Figure 1. Htt‐polyQ aggregates recruit LUBAC components.

• A
  HOIP, HOIL‐1L, and SHARPIN co‐localize with Htt‐Q97 aggregates. SH‐SY5Y cells co‐expressing Htt‐Q25‐GFP or Htt‐Q97‐GFP (green) and HOIP, HOIL‐1L, SHARPIN, or HHARI (red); DAPI (blue). Scale bar, 10 μm.
• B, C
  HOIP co‐localizes with Htt inclusion bodies in human HD frontal cortex. Perinuclear Htt aggregates visualized by immunofluorescence (B) and DAB immunohistochemistry (C) in human HD frontal cortex. Scale bar, 10 μm (B), 15 μm (C).

Data information: See also Fig EV1.