Comparison 5.

Vaccine treatment versus standard therapies in first‐line therapy of metastatic renal cell carcinoma

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 1‐year mortality	2	1034	Risk Ratio (M‐H, Random, 95% CI)	1.10 [0.91, 1.32]
2 Overall survival	2	1071	Hazard Ratio (Fixed, 95% CI)	1.14 [0.96, 1.37]
3 Adverse events (grade ≥ 3)	2	1065	Risk Ratio (M‐H, Random, 95% CI)	1.16 [0.97, 1.39]
4 Progression‐free survival	1	339	Hazard Ratio (Random, 95% CI)	1.05 [0.87, 1.27]
5 Tumour remission	2	1071	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.76, 1.13]