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. 2019 Apr 17;41(1):314–325. doi: 10.1080/0886022X.2019.1602054

Figure 1.

Figure 1.

Characteristics of chronic ischemic reperfusion injury (chronic I/R) and sham control by blood urea nitrogen (BUN; A), serum creatinine (Scr; B) and serum interleukin-6 (IL-6; C). The alteration in liver (D–F) and intestinal (G–I) cytochrome P3A11 (CYP3A11) expression and activity using midazolam or testosterone as substrates together with intestinal drug transporters expression (MDR1a, MRP2, and OATP3; J–L) were also demonstrated. The parameters were measured at 0, 2 and 4 weeks post-right nephrectomy, and the data from normal mice were used for 0-week time point.