Table 4.

Cytokines and Aβ 1–42 secretion profile in mixed hippocampal cultures stimulated with purified LPS of serotypes a, b, or c of Aa.

IL-1β	Fold change	IL-6	Fold change	TNF-α	Fold change	Aβ1-42	Fold change
Serotype a	0.903	Serotype a	1,009	Serotype a	0.613	Serotype a	1,545
	p = 0.978		p = 1.000		p = 0.585		p = 0.035
Serotype b	1,624	Serotype b	1,409	Serotype b	1,772	Serotype b	2,001
	p = 0.023		p = 0.020		p = 0.038		p < 0.0001
Serotype c	1,216	Serotype c	1,215	Serotype c	1,134	Serotype c	1,831
	p = 0.635		p = 0.274		p = 0.955		p < 0.0001

Table 4: The Table shows cytokine and Aβ_1-42 secretion levels in mixed hippocampal cultures treated with purified LPS (50 ng/mL) of serotypes a, b, or c of Aa. Analysis of secretion levels of the cytokines IL-1β, IL-6, and TNF-α and of Aβ_1-42 in mixed hippocampal cultures treated with purified LPS (50 ng/mL) of serotypes a, b, or c of Aa was performed. Data are presented as fold of control calculated from 10 independent experiments. p values: in comparison to non-induced controls. The concentrations of each molecule in the cell culture supernatants of non-induced controls were in pg/mL (IL1β: 143.54 ± 21.47; IL-6: 174.67 ± 29.49; TNF-α: 79.88 ± 26.30 and Aβ_1-42: 24.81 ± 9.03, presented as mean ± SD). IL: Interleukin, TNF: Tumor Necrosis Factor.