Table 2.

Cytogenetic findings in various cells/nuclei from patients with osteoarthritis

	Karyotype and FISH resultsa
	Peripheral	Nuclei		Synovial fibroblasts
	blood	extracted from	Collagenase
Patient	lymphocytes	synovial tissueb	digest	P-1	P-4
ES37	46,XY	n.a.	n.a.	47,XY,+7[1]/46,XY [49]	47,XY,+7[2]/46, XY [48]
ES52	46,XX	n.a.	n.a.	46,XX	n.a.
ES53	46,XY	n.a.	n.a.	46,XY	n.a.
ES54	46,XX	n.a.	n.a.	46,XX	n.a.
L09	46,XX	n.a.	n.a.	47,XX,+7[12]/48,XX,+7,+8[5];46,XX[33]	n.a.
L11	46,XX	n.a.	n.a.	46,XX	n.a.
EB8		46,XY	n.a.	46,XY	n.a.
	FISH:normal	FISH:+7 [4%];+8 [4%]; +9 [3%];-18 [7%]; incl. polyploid [1%]		FISH:+7 [17%];+8 [7%];+9 [9%]; -18 [19%]
EB9	46,XX	n.a.	n.a.	47,XX,+7[2]	n.a.
	FISH:normal		FISH:+7 [52%]; -9 [4%]	FISH:+7 [n.a.]; -9 [25%]
EB10	46,XX	n.a.	n.a.	46,XX	n.a.
	FISH:normal		FISH:+6 [6%];+7 [20%];+8 [11%];-8 [2%];-18 [8%]	FISH:+7 [32%];-8 [10%];-18 [18%]
EB11	46,XX		n.a.	47,XX,+7[3]/46,XX[7]	47,XX,+7[3]/46,XX[6]
	FISH:normal	FISH:+4 [3%];+7 [8%];+18 [0%]	FISH:+4 [3%]; +7 [19%];+18 [2%]	FISH:+4 [7%];+7 [15%];+18 [8%]; incl. polyploid [7%]
EB12	45,X[10]/46,XX[17]		n.a.	47,XX,+7,+4 or +5[3]/46,XX[4]	46,XX
	FISH:-X [32%]	FISH:+4 [0%];+7 [12%];+8 [12%];+9 [4%]		FISH:+4 [4%];+7 [42%];+8 [0%];+9 [11%]	FISH:+4 [2%];+7 [36%];+8 [1%];+9 [6%]
EB13	46,XY	n.a.	n.a.	46,XY	46,XY
	FISH:normal		FISH:+7 [15%];-9 [3%];+12 [0%]	FISH:+7 [37%];-9 [8%];+12 [11%]	FISH:+4 [8%];+7 [16%]; +9 [5%];-9 [25%];+12 [6%]
EB14	46,XX		n.a.	47,XX,+7[3]/46,XX[7]	46,XX,+7,+8,-15,-21[1]/48,XX,+7,+9[1]/47,XX,+7[1]/48,X,+7,+8,+9[1]/46,X,-X,+7,-17,+mar[1]/46,XX,t(5;11)(q23;q12)[1]/48,X,-X, +5,+7,+8[1]/46,XX[1]
	FISH:normal	FISH:+7 [14%];+8 [0%];+X [4%]	FISH:+7 [10%];+8 [0%];+X [6%]	FISH:+7 [36%];+8 [2%];+X [0%]	FISH:+7 [34%];+8 [8%];+X [6%]
EB15	46,XX	n.a.	n.a.	46,XX	n.a.
	FISH:normal			FISH:+6 [7%];+7 [10%];+8 [7%];+9 [10%];incl. polyploid [7%]	FISH:+6 [12%];+7 [16%];+8 [7%];+9 [10%];incl. polyploid [4%]
EB16	46,XX	n.a.	n.a.	n.a.	n.a.
	FISH:normal		FISH:+6 [5%]; +7 [18%];+8 [0%]; -X [18%]		FISH:+6 [26%];+7 [26%];+8 [35%];+X [17%];incl. polyploid [17%]
EB17	46,XX	n.a.	46,XX,chrb(1)(q12)[2]/46,XX[4]	46,XX	n.a.
	FISH:normal		FISH:+4 [17%];+6 [3%];+12 [1%]	FISH:+4 [16%];+6 [6%];+12 [5%];incl. polyploid [1%]
EB18	46,XX	n.a.	46,XX	46,XX	n.a.
	FISH:normal		FISH:+7 [1%];+8 [0%];+9 [2%]	FISH:+7 [5%];+8 [4%];+9 [1%]	FISH: +7 [18%];+8 [18%];+9 [18%];incl. polyploid [3%]
EB19	46,XX		46,XX	47,XX,+7[2]/46,XX[7]	47,XX,+7[2]/46,XX[6]
	FISH:normal	FISH:+7 [18%];+8[2%];+9 [4%];+12 [4%];incl. polyploid [2%]	FISH:+7 [14%];+8 [0%];+9 [0%];+12 [0%]	FISH:+7 [10%];+8 [0%];+9 [4%];+12 [7%]	FISH:+7 [26%];+8 [18%];+9 [7%];+12 [8%];incl. polyploid [7%]
EB21	46,XX	n.a.	46,XX	46,XX	n.a.
	FISH:normal		FISH:+4 [17%];+6 [7%];+7 [11%];+9 [17%]; incl. polyploid [5%]	FISH:+4 [3%];+6 [3%];+7 [5%];+9 [3%]; incl. polyploid [1%]	FISH:+4 [3%];+6 [4%];+7 [11%];+9 [3%]; incl. polyploid [3%]
EB22	46,XY	n.a.	n.a.	46,XY	n.a.
	FISH:normal		FISH:+4 [4%]; +7 [7%];+9 [3%]; incl. polyploid [1%]	FISH:+4 [2%];+7 [6%];+9 [1%]; incl. polyploid [1%]	FISH:+4 [8%];+7 [8%]; +9 [7%]
EB24	46,XX		n.a.	46,XX	n.a.
	FISH:normal	FISH:+4 [0%];+6 [3%];+7 [7%];+9 [3%]	FISH:+4 [8%];+6 [8%];+7 [25%];+9 [8%]; incl. polyploid [7%]	FISH:+4 [9%];+6 [2%];+7 [33%];+9 [3%]; incl. polyploid [2%]	FISH:+4 [2%];+6 [2%];+7 [24%];+9 [3%]; incl. polyploid [2%]
EB29	46,XX	n.a.	n.a.	n.a.	n.a.
	FISH:normal
J4	n.a.		n.a.	46,XX	46,XX
		FISH:+4 [5%];+7 [14%]; incl. polyploid [1%]		FISH:+4 [1%];7 [6%]; incl. polyploid [1%]
J5	n.a.		n.a.	n.a.	n.a.
		FISH:+4 [5%];+7 [13%]

^aSee Table 1. ^b Only FISH data are available. incl. = including; n.a. = not analyzed (Karyotype and/or FISH); P-1 = passage 1; P-4 = passage 4.