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. 2019 Feb 20;24(3):346–361. doi: 10.1177/2472555218823171

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© 2019 Society for Laboratory Automation and Screening

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — (A) Layout of samples and controls in assay plates for the TbPTR1 target-based screen against the MycoDiverse natural products library. (B) Dose-response curves (DRC) and average IC₅₀ values across all 34 assay plates for each reference compound were for methotrexate 8.6 ± 2.3 nM, F0046 73 ± 27 nM, and pyrimethamine 16.7 ± 5.0 nM. Standard deviations are within ±10% of the values.