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. 2019 Feb 1;2(2):e187800. doi: 10.1001/jamanetworkopen.2018.7800

Figure 2. Meta-analysis of Motor Improvement and Levodopa Equivalent Daily Dose (LEDD) Reduction After Subthalamic Nucleus Deep Brain Stimulation.

Figure 2.

A, The DerSimonian and Laird (D-L) meta-analysis method produced slightly less precise estimates compared with the Hartung-Knapp-Sidik-Jonkman (HKSJ) method. Both methods produced similar findings, except for the GBA gene owing to the extremely high heterogeneity and small number of studies. The presurgical motor outcome (Unified Parkinson’s Disease Rating Scale Part III [UPDRS-III] score) associated with levodopa is reported in eTable 8 in the Supplement. B, Both D-L and HKSJ meta-analysis methods produced similar findings for all genes. Error bars represent the 95% CI of the mean changes reported.