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. 2018 Dec 20;38(16):3093–3101. doi: 10.1038/s41388-018-0625-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Altered function of mitochondria in LAM cells. a qRT-PCR analysis of mitochondrial gene expression in individual LAM cell lines (n = 4) compared to normal SMC controls (n = 2). Data are presented as mean log RQ ± SEM and significant changes are marked as asterisk (P < 0.05). b Flow cytometric analysis of RH-123 fluorescence intensity in individual LAM cell lines (n = 4) compared to normal SMC controls (n = 2). Data are presented as mean RFU ± SEM; significant changes are marked as asterisk (P < 0.05). c Oxygen consumption rate and glycolysis were measured by SeaHorse XF96 in individual LAM (n = 4) cell lines and normal SMC control cells (n = 2). Representative OCR and ECAR data are presented as mean ± SEM, significant changes are marked as asterisk (* P < 0.05). d Measurements of mitochondrial activity. Oxygen consumption rate of mitochondria measured using Oroboros (blue line = oxygen concentration, red line = oxygen flux per volume; quantification of oxygen consumption (area under the curve). e TrxR activity measured in individual LAM (n = 4) and normal, bronchial SMC control (n = 2) samples. Data are TrxR; activity is presented as mean of nmol min/ml ± SEM; significant changes are marked as asterisk (P < 0.05)