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. 2018 Dec 21;38(16):2994–3002. doi: 10.1038/s41388-018-0623-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Identification of the BRAF p.V504_R506dup mutation in the PA patient TC0011. a Split-screen view from the integrative genomics viewer visualizing the 9 nucleotide insertion at the end of the exon 12, causing the repetition of the amino acid 504–506 VLR. b Schematic localization of the 9 bp insertion (p.V504_R506dup) in the Kinase domain at chr7:g.140477790 (indicated by an arrow). The middle panel shows BRAF functional domains and amino acid positions (1–766). The top panel depicts BRAF mutations reported in COSMIC (http://cancer.sanger.ac.uk/cosmic) and PeCan database (https://pecan.stjude.org) related to tumors in the central nervous system. The figure was built and adapted using the PeCan data portal (https://pecan.stjude.org/proteinpaint)