Fig. 2.

a Molecular and cytogenetic characterization of IDH1-mutated patients. Illustration of all 106 samples, each column represents one patient. All 25 additionally analyzed genes as well as karyotype information are given for each patient. Patients are grouped by IDH1 R132C, R132H, and R132 other. Light gray: wild type, red: mutated, orange: variant of uncertain significance, dark blue: aberrant karyotype, light blue: normal karyotype, white: no data available. The number of additional mutations per patient is illustrated as bar chart above the graph. The mutation frequencies of single genes are given as bar chart at the right. b Spider plot illustrating the mutation frequencies (in %) of ASXL1, NPM1, RUNX1, and SRSF2 mutations for the single groups of IDH1 R132C, R132H, and R132 other